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IGFBP-3 R

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IGR-H5259 Human Human IGFBP-3 R / TMEM219 Protein, Fc Tag (MALS verified)
IGR-H5259-structure
IGR-H5259-sds
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Part of Bioactivity data

IGR-H5259-ELISA
IGFBP-3 R MALS images

The purity of Human IGFBP-3 R, Fc Tag (Cat. No. IGR-H5259) is more than 85% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

Synonym Name

IGFBP-3 R,TMEM219,Insulin-like growth factor-binding protein 3 receptor,Transmembrane protein 219

Background

IGFBP-3 R, also know as TMEM219, is a cell death receptor specific for IGFBP3. IGFBP-3R is expressed on the cell surface, interacts specifically with IGFBP-3 but not other IGFBP species. It activates initiator caspase-8, and mediates IGFBP-3-induced apoptosis in vitro and tumor suppression in vivo.

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